French network of hepatic tumor biobanks
Sunday, April 11, 2021

A national collection of liver tumours: general presentation

The main liver centres in France have joined their effort to collect, preserve and distribute tissue samples from liver tumors, including hepatocellular carcinomas, according to the recommendations for Biological Resources Centres (BRC) released by the Organisation for Economic Cooperation and Development (OECD)[1] and the European Council[2] which were implemented in France by Inserm and INCa.[3,4] This led to the creation of the Liver cancer biobanks network which is recognized by the Ministry of research and the Ministry of health and sponsored by the main research agencies, namely Inserm and INCa.[5] The network is member of the national "Biobanques" infrastructure[6] which is fully integrated into the EU-sponsored « Bioanking and Biomolecular Research Infrastructure »[7], and the « International Cancer Genome Consortium ».[8]

Samples are collected and stored locally, whereas related annotations are remotely collected within a central database. The management of the network includes a Scientific Committee, an Executive Board and an Epidemiology and Management Coordinating Centre. Samples are made available to research groups following acceptance of research projects submitted to the scientific committee.

Samples from the Liver cancer biobanks network were used in recent works aiming at identifying key genomic alterations occurring in the development of hepatocellular carcinomas, as well as new set of biomarkers, including transcriptomic and proteomic signatures, and candidate targets for anti-cancer drugs.

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Benign tumor
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